Multiple Myeloma Symptoms Rash

Multiple myeloma symptoms rash - Multiple myeloma is a type of cancer that affects the bone marrow, the training system of blood of the organism. The plasma cells (a type of white blood cell) become abnormal and multiply rapidly, which hinders the production of normal blood cells. The excessive growth of malignant cells in the bone marrow can also weaken the bones, especially in the back and ribs, with onset of pain and bone fractures.
Multiple Myeloma Symptoms Rash

Multiple myeloma is uncommon, in Spain today there are about 10000 cases every year are diagnosed 2000 more. Although it is unknown the exact cause, multiple myeloma can be controlled in most patients, sometimes for many years. The development of drugs novel has helped to control the multiple myeloma in a larger number of patients and has been associated with an increased survival.

Symptoms: Multiple Myeloma Symptoms Rash

Patients diagnosed of multiple myeloma does not usually manifest symptoms in the early stages of the disease. The signs to be alert for include:
  • Fractures: bone damage is the most serious problem when it is diagnosed myeloma. It is because the cells mielomatosas produce substances called cytokines, which can make the bone cells (osteoclasts) to destroy the adjacent bone. When it has been destroyed more than 30% of the bone, the x-rays show a thinning of the bone (osteoporosis) or the presence of holes dark (lytic lesions). The weakened area of bone can break, which is known as a pathological fracture. To prevent the bone destruction, the doctor may recommend the administration of drugs that prevent osteoclasts from destroying the bone (for example, Zometa®, or Aredia®).
  • Bone pain: it is especially frequent in the dorsal region or lumbar spine, the ribcage and the hips. The pain can be mild or intense depending on the size of the lesion, the speed with which it has developed and if there has been a fracture or nerve compression. Normally, the movement becomes much worse the pain.
  • Fatigue: since the cells mielomatosas move to the other blood cells in the bone marrow, decreases the number of red blood cells in the body. This gives rise to the symptoms of tiredness.
  • Infection: since the cells mielomatosas displace normal white blood cells, which fight infection, there is a risk of infection. The symptoms of infection depend on the location of the same. Pneumonia, infections of bladder or kidney, sinus and skin infections are frequent.
  • Hypercalcaemia: the presence of a high amount of calcium in the bloodstream. When you destroy the bone, calcium is released into the blood circulation. As you increase the amount, the kidneys are not able to get rid of the calcium in the urine. Symptoms of hypercalcemia consist of thirst, nausea, constipation, and mental confusion.
See also: Multiple Myeloma symptoms of end Stage
The presence of one or more of the symptoms cited does not necessarily imply that you have multiple myeloma. However, it is important that you see these symptoms to your doctor, since they may indicate other health problems.

it's a blood disorder, usually arising in the bone marrow and is closely associated with lymphoma and leukemia. Effective myeloma treatment for today does not exist, therapy is aimed at slowing disease progression.

In myeloma, a certain kind of white blood cells called plasma begins to multiply abnormally in the bone marrow. Plasma cells are responsible for producing antibodies that help the body fight off infections. When myeloma such cells isolated in bone and blood harmful protein called immunoglobulin, which gradually accumulates in the body. Inside the bone marrow the myeloma cells secrete chemicals into the plasma, which leads to weakening and bone fractures. With the development of myeloma the blood of pathogenic cells spread to other parts of the body.

Multiple Myeloma Symptoms Rash: The causes of Myeloma

The causes of myeloma are not known, but major risk factors include:

  • the age of 65
  • male
  • African-American race
  • the presence of a relative with the disease

Also, the myeloma may develop in people suffering from such diseases as monoclonal gammopathy undetermined significance and solitary plasmacytoma.

Symptoms of multiple myeloma
In the early stages of myeloma may not be evident, but with the development of the disease plasma cells accumulate in bones and cause the following symptoms:

  • bone pain due to lytic disease
  • weakness and fatigue caused by anemia
  • weight loss
  • hypercalcemia, causing excessive thirst, constipation, confusion of consciousness
  • kidney problems
  • infections caused by immunoglobulins

Plasma cells can accumulate under the skin in the form of visible purple lumps, these tumors are called plasmacytoma.

Diagnosis of Myeloma
Usually diagnosis of multiple myeloma, the prognosis depends on many factors, happening by chance on the abnormal results of blood tests performed for other reasons. The doctor may suspect the disease because of the following results of laboratory testing of blood:

  • High level of calcium in the blood (hypercalcemia)
  • anemia
  • elevated creatinine, indicating the improvement of renal function
  • a high level of protein in the blood in combination with low levels of albumin
  • protein in the urine

If the doctor Cancer Center Blood suggests the presence of myeloma onanii laboratory blood and urine tests, there shall be pictures of bone machine. Myeloma lesions have a very characteristic pattern and identifiable, even on a simple x-ray picture. The most important tests are the following tests:

  • The serum protein electrophoresis (SPEP) and immunoelectrophoresis analysis of proteins (IFE)
  • Urine protein electrophoresis (UPEP) and immunoelectrophoresis (UFE)

97% of people with myeloma have abnormal results of these tests. In this case, the doctor may recommend a bone marrow biopsy to confirm the diagnosis and to appoint adequate treatment of myeloma.

Multiple Myeloma Symptoms Rash: The treatment of myeloma

Complex therapy of multiple myeloma helps to ease the symptoms. The initial treatment of myeloma represents an induction therapy, involving the use of various drugs. Some people may have a transplant of autologous stem cells taken from the patient after induction therapy.

Chemotherapy is considered less effective in treatment of myeloma than stem cell transplantation, but, nevertheless, this treatment is often used in cases where transplantation is contraindicated in the patient because of the high risk of complications. To treat multiple myeloma, doctors generally use a combination of drugs, which may include:

  • Adriamycin(doxorubicin),
  • Alkeran(melphalan),
  • Cytoxan(cyclophosphamide),
  • Oncovin(vincristine),
  • Pomalyst(pomalidomide),
  • Revlimid(lenalidomide),
  • Thalomid(thalidomide),
  • Velcade(bortezomib).

Corticosteroids (prednison and dexamethasone) are usually prescribed with chemotherapy to reduce side effects. The hormone interferon is used as the drug contributing to the persistence of remission myeloma after chemotherapy. Radiotherapy is also often used by physicians in the treatment of myeloma and suggests the direction of the beam of energy to the bones or other parts of the body damaged by the myeloma. High-energy rays to destroy pathogenic cells, sensitive to radiation, resulting in weakened bone stabiliziruemost and relieves pain.

Multiple myeloma can cause a number of complications that require additional treatment. Such complications include:

  • Back pain. Assigned pain medication or wearing a back brace that can help ease the pain.
  • Kidney problems in certain cases require dialysis.
  • Infections involve antibiotic therapy.
  • The loss of bone mass. For the treatment of this pathology are assigned are medications such as bisphosphonate, pamidronate (Aredia) or zoledronic acid (Zometa), active substances which bind to the surface of the bone and help prevent bone loss.
  • Anemia in myeloma involves the appointment of an injection of hormones that stimulates the production of red blood cells.

Research on finding effective treatments for myeloma blood, including clinical trials to identify more effective chemotherapy drugs continue. Myeloma may have different prognoses depending on the severity of the disease and the speed of its flow. Some people with myeloma can live for many years with minimal symptoms, for others, the disease progresses very quickly and leads to death within a short time.

To predict survival of a patient with multiple myeloma developed a test that involves checking the blood levels of two substances albumin and beta-2-microglobulin. High levels of albumin and low levels of beta-2-microglobulin in the blood indicates a high the patient's chances for long-term survival. The definition of the type and degree of aggressiveness of the myeloma helps doctors develop the best treatment plan, however, even the most accurate system of prediction is not possible to determine exactly how long a person will live.