Cold Virus Cancer Treatment
Types of cancer in this study; Non-muscular invasive bladder cancer affects about 40,000 Americans per year, according to the American Cancer Society. Cold virus cancer treatment - The existing treatments are very invasive, have significant side effects and the patients usually fall.
Non-muscular invasive bladder cancer is a very common disease that requires an intrusive and long-term treatment plan. The current treatment is ineffective and toxic to some patients and there is an urgent need for new therapies, said the study coordinator and professor of Medical oncology at the University of Surrey.
Cold Virus Kills Cancer Cells?
The patients in this study received CVA21, a type of Coxsackiev virus directly into their bladder through a catheter one week before surgery. When the researchers examined tissue samples postoperatively, they found that the virus infected only cancer cells, leaving only healthy tissue. Cold virus cancer treatment - Not only that, urine samples from patients show that the virus continues to replicate and attack more cancer cells. In one patient, they found no trace of cancer during the operation, only one week after the patient received therapy.
Coxsackievirus can help revolutionize treatment for this type of cancer. A reduction in tumor load and an increase in the death of cancer cells was observed in all patients and eliminated all traces of the disease in one patient after only one week of treatment, indicating potential efficacy.
Bladder tumors are usually protected from the immune system, which means that they cannot intervene and attack cancer, which is commonly referred to in medicine as a "cold" (cold) tumor. The researchers suspect that treatment with CVA21 causes inflammation in the tumor cells, which causes the entry of immunologic cells that are forced to kill the cancerous cells, making the tumors "hot ".
The alteration of the "hot" tumors is the main objective of several immunotherapeutic treatments with virus, T-cell or immunologic checkpoint inhibitors, such as those that block PD-1 or CTLA-4. Researchers are studying that it is unlikely that tumors "cold " respond, and how to push the button and make tumors prone to immunotherapy is a very hot research field. The virus continues to be tested on various types of cancer, with surprising results in metastatic melanoma from the first FDA-approved viral therapy for cancer called TVEC.
Cold virus cancer treatment - A very promising aspect of this experiment is that none of the patients presented severe toxicity by the treatment of the virus. Long-term follow-up of patients treated with viruses is necessary and also validation in larger assays. If researchers follow the current tendency to further increase the immunological response after treatment with the virus, they can combine treatment with immunologic checkpoint inhibitors, such as anti-PD-1 medications.
Coxsackievirus can help revolutionize treatment for this type of cancer. A reduction in tumor load and an increase in the death of cancer cells was observed in all patients and eliminated all traces of the disease in one patient after only one week of treatment, indicating potential efficacy.
Bladder tumors are usually protected from the immune system, which means that they cannot intervene and attack cancer, which is commonly referred to in medicine as a "cold" (cold) tumor. The researchers suspect that treatment with CVA21 causes inflammation in the tumor cells, which causes the entry of immunologic cells that are forced to kill the cancerous cells, making the tumors "hot ".
The alteration of the "hot" tumors is the main objective of several immunotherapeutic treatments with virus, T-cell or immunologic checkpoint inhibitors, such as those that block PD-1 or CTLA-4. Researchers are studying that it is unlikely that tumors "cold " respond, and how to push the button and make tumors prone to immunotherapy is a very hot research field. The virus continues to be tested on various types of cancer, with surprising results in metastatic melanoma from the first FDA-approved viral therapy for cancer called TVEC.
Cold virus cancer treatment - A very promising aspect of this experiment is that none of the patients presented severe toxicity by the treatment of the virus. Long-term follow-up of patients treated with viruses is necessary and also validation in larger assays. If researchers follow the current tendency to further increase the immunological response after treatment with the virus, they can combine treatment with immunologic checkpoint inhibitors, such as anti-PD-1 medications.